Is there a way to disable a certain time on a reoccurring day of the we

Is there a way to disable a certain time on a reoccurring day of the week?

Ex: Fridays after 5pm

It's not possible to conditionally disable the days or certain time. But you may do the following: 

1. Add a hidden time field with the current time, this will help you to trigger the condition at the desired time frame. 

2. You will need to add an additional date picker where the desired day is disabled, for example, Friday: 

Then you only need conditions to show the correct date field according to the current time, you can set show/hide conditions, here is an example: 

I hope this helps.