Can I make a question conditionally required?

For example, if answer to question 1 is "A," question 2 is required. If the answer to question 1 is "B," question 2 is not required.

You can check this guide to learn more about conditional logic: https://www.jotform.com/help/57-Smart-Forms-Using-Conditional-Logic 

For the specific functionality to make fields require or not based on user's input, you can refer to this guide specifically: https://www.jotform.com/help/367-How-to-Make-a-Field-Required-Based-on-User-s-Answer. That guide is also mentioned in the first link I shared.

I hope that helps.