Limb Development Quiz
Test your knowledge on the processes and mechanisms of limb development.
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Which of the following is the earliest signaling center in vertebrate limb development?
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Apical ectodermal ridge (AER)
Zone of polarizing activity (ZPA)
Progress zone
Somites
Select all processes involved in limb bud formation.
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Cell proliferation
Cell migration
Apoptosis
Neural crest cell differentiation
Other
Match the signaling molecule to its primary role in limb development.
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Rows
Primary Role
FGF8
AER maintenance
Anterior-posterior patterning
Proximal-distal growth
Digit formation
SHH
AER maintenance
Anterior-posterior patterning
Proximal-distal growth
Digit formation
HOXA13
AER maintenance
Anterior-posterior patterning
Proximal-distal growth
Digit formation
Which gene is most associated with anterior-posterior patterning in limb development?
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SHH
FGF10
BMP4
WNT7A
Rate your confidence in your knowledge of limb development.
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1
2
3
4
5
During which embryonic week does limb bud outgrowth typically begin in humans?
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Please Select
Week 3
Week 4
Week 5
Week 6
Short answer: Name one congenital limb malformation and briefly describe it.
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Which of the following is NOT a function of the apical ectodermal ridge (AER)?
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Maintains proliferation in the progress zone
Controls anterior-posterior patterning
Prevents premature differentiation
Promotes outgrowth of the limb bud
What is the primary role of apoptosis in limb development?
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Formation of joints
Removal of interdigital tissue
Patterning of muscles
Vascularization
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