How can I design a form that allows the receipient to respond only once?

Hello,

Thank you for contacting us.

You can set your Form to recieve unique submissions, this will allow the user submit the Form only once,you will find further assistance setting unique submissions on this guide : 

http://www.jotform.com/help/64-How-to-Set-Unique-Submissions-on-a-Form

I hope that helps.

If you need further assistance, feel free to contact us.