Is there a way to set different e-mail addresses for various form submissions?

For example. the "Contact Us" form submissions get sent to a different e-mail address than the "Return Request" forms?

Yes, it's possible to do that, to get more info about how to add multiple recipients to your form, please check this guide: https://www.jotform.com/help/39-Send-Notifications-to-Multiple-Recipients 

If you have any question, let us know.